Autophagy in Infection and Immunity directory
An Overview of the Molecular Mechanism of Autophagy .......................... 1
Zhifen Yang and Daniel J. Klionsky
Macroautophagy Signaling and Regulation ................................................. 33
Audrey Esclatine, Magali Chaumorcel, and Patrice Codogno
Physiological Functions of Autophagy .......................................................... 71
Noboru Mizushima
Autophagy and Lymphocyte Homeostasis .................................................... 85
Heather H. Pua and You-Wen He
Autophagy and Innate Recognition Systems ................................................ 107
Michal Caspi Tal and Akiko Iwasaki
Autophagy in MHC Class II Presentation of Endogenous Antigens .......... 123
Monique Gannagé and Christian Münz
Role of Autophagy and Autophagy Genes in
Inflammatory Bowel Disease .......................................................................... 141
Ken Cadwell, Thaddeus S. Stappenbeck, and Herbert W. Virgin
Autophagy in Immunity Against Mycobacterium tuberculosis:
a Model System to Dissect Immunological Roles of Autophagy ................. 169
Vojo Deretic, Monica Delgado, Isabelle Vergne, Sharon Master,
Sergio De Haro, Marisa Ponpuak, and Sudha Singh
Autophagy in Immunity Against Intracellular Bacteria ............................. 189
Ju Huang and John H. Brumell
Group A Streptococcus: A Loser in the Battle with Autophagy ................. 217
Tamotsu Yoshimori and Atsuo Amano
Autophagy Subversion by Bacteria ............................................................... 227
Emanuel Campoy and María I. Colombo
Autophagy in Immunity Against Toxoplasma gondii ................................... 251
Carlos S. Subauste
Autophagy in Mammalian Antiviral Immunity ........................................... 267
Anthony Orvedahl and Beth Levine
Something Old, Something New: Plant Innate
Immunity and Autophagy .............................................................................. 287
Montrell Seay, Andrew P. Hayward, Jeffrey Tsao, and S.P. Dinesh-Kumar
Autophagy in HIV-Induced T Cell Death ..................................................... 307
Lucile Espert and Martine Biard-Piechaczyk
Subversion of the Cellular Autophagy Pathway by Viruses ....................... 323
Karla Kirkegaard
Index
Autophagy in Infection and Immunity Wonderful abstract
Abstract Autophagy is a highly conserved cellular degradation process in which portions of cytosol and organelles are sequestered into a double-membrane vesicle,an autophagosome, and delivered into a degradative organelle, the vacuole/lysosome,for breakdown and eventual recycling of the resulting macromolecules. This process relieves the cell from various stress conditions. Autophagy plays a critical role during cellular development and differentiation, functions in tumor suppression, and may be linked to life span extension. Autophagy also has diverse roles in innate and adaptive immunity, such as resistance to pathogen invasion. Substantial progress has been made in the identification of many autophagy-related (ATG) genes that are essential to drive this cellular process, including both selective and nonselective types of autophagy. Identification of the ATG genes in yeast, and the finding of orthologs in other organisms, reveals the conservation of the autophagic machinery in all eukaryotes. Here, we summarize our current knowledge about the machinery and molecular mechanism of autophagy.
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